Primary cilia-associated signalling in squamous cell carcinoma of head and neck region

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00598091" target="_blank" >RIV/67985904:_____/24:00598091 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/24:00138372 RIV/61988987:17110/24:A2503AK6 RIV/62157124:16170/24:43881224 RIV/00843989:_____/24:E0111111
Result on the web
<a href="https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1413255/full" target="_blank" >https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1413255/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fonc.2024.1413255" target="_blank" >10.3389/fonc.2024.1413255</a>

Result language
angličtina
Original language name
Primary cilia-associated signalling in squamous cell carcinoma of head and neck region
Original language description
Squamous cell carcinoma (SCC) of the head and neck originates from the mucosal lining of the upper aerodigestive tract, including the lip, tongue, nasopharynx, oropharynx, larynx and hypopharynx. In this review, we summarise what is currently known about the potential function of primary cilia in the pathogenesis of this disease. As primary cilia represent a key cellular structure for signal transduction and are related to cell proliferation, an understanding of their role in carcinogenesis is necessary for the design of new treatment approaches. Here, we introduce cilia-related signalling in head and neck squamous cell carcinoma (HNSCC) and its possible association with HNSCC tumorigenesis. From this point of view, PDGF, EGF, Wnt and Hh signalling are discussed as all these pathways were found to be dysregulated in HNSCC. Moreover, we review the clinical potential of small molecules affecting primary cilia signalling to target squamous cell carcinoma of the head and neck area.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project
<a href="/en/project/NV19-08-00383" target="_blank" >NV19-08-00383: Prognostic and predictive markers of squamous cell carcinoma invasion in the oral cavity and oropharynx</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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