Unifying framework explaining how parental regulatory divergence can drive gene expression in hybrids and allopolyploids

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00600014" target="_blank" >RIV/67985904:_____/24:00600014 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/24:00600014 RIV/60076658:12310/24:43908288 RIV/60076658:12520/24:43908288 RIV/61988987:17310/24:A2503ANE

Result on the web

<a href="https://www.nature.com/articles/s41467-024-52546-5" target="_blank" >https://www.nature.com/articles/s41467-024-52546-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41467-024-52546-5" target="_blank" >10.1038/s41467-024-52546-5</a>

Result language

angličtina

Original language name

Unifying framework explaining how parental regulatory divergence can drive gene expression in hybrids and allopolyploids

Original language description

Hybridization and polyploidy are powerful evolutionary forces, inducing a range of phenotypic outcomes, including non-additive expression, subgenome dominance, deviations in genomic dosage, and transcriptome downsizing. The reasons for these patterns and whether they are universal adaptive responses to genome merging and doubling remain debated. To address this, we develop a thermodynamic model of gene expression based on transcription factor (TF)-promoter binding. Applied to hybridization between species with divergent gene expression levels, cell volumes, or euchromatic ratios, this model distinguishes the effects of hybridization from those of polyploidy. Our results align with empirical observations, suggesting that gene regulation patterns in hybrids and polyploids often stem from the constrained interplay between inherited diverged regulatory networks rather than from subsequent adaptive evolution. In addition, occurrence of certain phenotypic traits depend on specific assumptions about promoter-TF coevolution and their distribution within the hybrid's nucleoplasm, offering new research avenues to understand the underlying mechanisms. In summary, our model explains how the legacy of divergent species directly influences the phenotypic traits of hybrids and allopolyploids.nHybridization and polyploidization influence gene expression with several prominent trends. This study uses a thermodynamic model to show that many observed gene expression patterns in hybrids and allopolyploids can be explained by regulatory divergence between parents, revealing the complex interplay of admixed regulatory networks.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Communications

ISSN

2041-1723

e-ISSN

2041-1723

Volume of the periodical

15

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

16

Pages from-to

8714

UT code for WoS article

001331421200024

EID of the result in the Scopus database

2-s2.0-85205985805