Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00604507" target="_blank" >RIV/67985904:_____/24:00604507 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/24:00604507 RIV/00216224:14110/24:00138597 RIV/00159816:_____/24:00081561
Result on the web
<a href="https://academic.oup.com/jbmr/article/39/12/1783/7826674?login=false" target="_blank" >https://academic.oup.com/jbmr/article/39/12/1783/7826674?login=false</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/jbmr/zjae173" target="_blank" >10.1093/jbmr/zjae173</a>
Alternative languages
Result language
angličtina
Original language name
Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy
Original language description
The article provides clear evidence that achondroplasia should be treated immediately after birth, not only to increase height (appendicular growth), but more importantly to prevent defective cranial skeletogenesis and associated severe neurological complications. Although later treatment promotes growth of the long bones (achondroplasia patients grow taller), the defective head skeleton that forms before and/or early after birth cannot be restored if therapy is not started immediately after birth. We also describe the limitations of postnatal treatment and make a strong case for the development of prenatal therapy for achondroplasia, which appears necessary for a comprehensive treatment of this condition.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Bone and Mineral Research
ISSN
0884-0431
e-ISSN
1523-4681
Volume of the periodical
39
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1783-1792
UT code for WoS article
001359521900001
EID of the result in the Scopus database
2-s2.0-85212329528