BRCA1 and BRCA2 as prognostic markers in oral squamous cell carcinoma: a minireview
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F25%3A00619151" target="_blank" >RIV/67985904:_____/25:00619151 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/25:00141128 RIV/61988987:17110/25:A2603CSI RIV/00843989:_____/25:E0111645
Result on the web
<a href="https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1528822/full" target="_blank" >https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1528822/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fonc.2025.1528822" target="_blank" >10.3389/fonc.2025.1528822</a>
Alternative languages
Result language
angličtina
Original language name
BRCA1 and BRCA2 as prognostic markers in oral squamous cell carcinoma: a minireview
Original language description
Oral squamous cell carcinoma (OSCC), a subset of head and neck cancers, primarily originates in the epithelial tissues of the oral cavity. Despite advancements in treatment, the mortality rate for OSCC remains around 50%, underscoring the urgent need for improved prognostic markers. This review explores the role of the BRCA1 and BRCA2 genes-traditionally associated with breast and ovarian cancers-in the context of OSCC. We discuss the molecular pathways involving BRCA genes, their potential as diagnostics and prognostic biomarkers, and their implications for personalized treatment strategies, including addressing chemotherapy resistance. Furthermore, this review emphasizes the significance of genome stability in cancer progression and examines both current and emerging methodologies for detecting BRCA mutations in OSCC patients. Despite limited prevalence of BRCA mutations in OSCC compared to other cancers, their role in DNA repair and therapeutic response underscores their potential as clinical biomarkers. However, standardized, multicenter studies are still needed to validate their utility in OSCC management. A better understanding of the role of BRCA genes in OSCC could pave the way for more effective therapeutic approaches and improved patient outcomes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30208 - Dentistry, oral surgery and medicine
Result continuities
Project
<a href="/en/project/NV19-08-00383" target="_blank" >NV19-08-00383: Prognostic and predictive markers of squamous cell carcinoma invasion in the oral cavity and oropharynx</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Oncology
ISSN
2234-943X
e-ISSN
2234-943X
Volume of the periodical
15
Issue of the periodical within the volume
MAR28
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
1528822
UT code for WoS article
001463362700001
EID of the result in the Scopus database
2-s2.0-105002227069