Evidence for Pathogen-Driven Selection Acting on HLA-DPB1 in Response to Plasmodium falciparum Malaria in West Africa
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985912%3A_____%2F25%3A00617884" target="_blank" >RIV/67985912:_____/25:00617884 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/ece3.70933" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ece3.70933</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ece3.70933" target="_blank" >10.1002/ece3.70933</a>
Alternative languages
Result language
angličtina
Original language name
Evidence for Pathogen-Driven Selection Acting on HLA-DPB1 in Response to Plasmodium falciparum Malaria in West Africa
Original language description
We investigated the molecular variation of four Human Leukocyte Antigens (HLA) class II genes (DRB1, DQA1, DQB1 and DPB1), directly involved in the immune response to parasitic infections, in more than 1000 individuals from 23 populations across North, East, Central and West Africa. We identified divergent genetic profiles for several (semi-) nomadic populations of the Sahel belt as a signature of their unique demography and observed significant genetic structuring supporting both substantial geographic and linguistic differentiations within West Africa. The most striking observation comes from linear modeling, demonstrating that the prevalence of Plasmodium falciparum, the primary pathogen of malaria in Africa, significantly explains a large proportion of the nucleotide diversity observed at the DPB1 gene. DPB1*01:01, a highly frequent allele in populations from Burkina Faso, is identified as a potential protective allele against malaria, suggesting that strong pathogen-driven positive selection at this gene has shaped HLA variation in Africa.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
60102 - Archaeology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Ecology and Evolution
ISSN
2045-7758
e-ISSN
2045-7758
Volume of the periodical
15
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
e70933
UT code for WoS article
001429401400001
EID of the result in the Scopus database
2-s2.0-85219091470