Two Mutations of Basic Residues within the N-Terminus of HMG-1 B Domain with Different Effects on DNA Supercoiling and Binding to Bent DNA.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F01%3A17013030" target="_blank" >RIV/68081707:_____/01:17013030 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Two Mutations of Basic Residues within the N-Terminus of HMG-1 B Domain with Different Effects on DNA Supercoiling and Binding to Bent DNA.

Original language description

Here we show that the lysine-rich part of the linker region between A and B domains of HMG-1, the 85TKKKFKD91 sequence that is attached to the N-terminus of the B domain within HMG-1, is a prerequisite for a preferential binding of the B domain to supercoiled DNA. The above sequence is also essential for a high-affinity binding of the B domain to DNA containing a site-specific major 1,2-d(GpG) intrastrand DNA adduct of cisplatin

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochemistry

ISSN

0006-2960

e-ISSN

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Volume of the periodical

40

Issue of the periodical within the volume

15

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

4769-4779

UT code for WoS article

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EID of the result in the Scopus database

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