Stimulation of nonspecific immunity, haemopoiesis and protection of mice against radiation injury by 1-adamantylamide-L-alanyl-D-isoglutamine incorporated in liposomes.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F01%3A17013050" target="_blank" >RIV/68081707:_____/01:17013050 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Stimulation of nonspecific immunity, haemopoiesis and protection of mice against radiation injury by 1-adamantylamide-L-alanyl-D-isoglutamine incorporated in liposomes.

Original language description

Adamantyle dipeptide (AdDP) protect mice against irradiation when administered s.c. 24h before lethal gamma-irradiation. Incorporation of AdDP in liposomes (L-AdDP) significantly improved radioprotective effect of AdDP and recovery of the pool of granulocyte-macrophage haemopoietic progenitor cells (GM-CFC) in a broad application time window (72h before and 48h after irradiation). L-AdDP significantly increased non-specific immunity against Candida albicans infectious model. L-AdDP could be therapeutically beneficial to moderate the haemopoietic damage and induce non-specific immunity to support the antimicrobial treatment of immunocompromised patients.Adamantyle dipeptide (AdDP) protect mice against irradiation when administered s.c. 24h before lethalgamma-irradiation. Incorporation of AdDP in liposomes (L-AdDP) significantly improved radioprotective effect of AdDP and recovery of the pool of granulocyte-macrophage haemopoietic progenitor cells (GM-CFC) in a broad application time wi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/PZ-Z2%2F25" target="_blank" >PZ-Z2/25: Imunotherapeutics for treatment and prevention of serious diseases.</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Immunopharmacology

ISSN

1567-5769

e-ISSN

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Volume of the periodical

1

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

167-175

UT code for WoS article

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EID of the result in the Scopus database

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