Comparison of relative toxic potencies of hydroxylated PCBs and quinones in hepatic and mammary cell lines.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F02%3A17023192" target="_blank" >RIV/68081707:_____/02:17023192 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Comparison of relative toxic potencies of hydroxylated PCBs and quinones in hepatic and mammary cell lines.

Original language description

A series of low-molecular-weight mono- and dihydroxylated PCBs (HO-PCBs), 2-(chlorophenyl)-1,4-benzoquinones (BQs) and 1,4-hydroquinones (HQs) were tested for their nongenotoxic potencies in several established in vitro cellular models. The data presented here show that both the low-molecular-weight PCB metabolites and the persistent HO-PCBs are capable of multiple nongenotoxic modes of action, including significant dioxin-like activity, modulation of ER-mediated activity and promotional effects associated with inhibition of intercellular communication.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

BO - Biophysics

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Organohalogen Compounds, vol. 56: Dioxin 2002.

ISBN

84-607-5184-8

ISSN

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e-ISSN

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Number of pages

4

Pages from-to

25-28

Publisher name

N/A

Place of publication

Barcelona

Event location

Barcelona [ES]

Event date

Aug 11, 2002

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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