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DNA-protein cross-linking by trans-[PtCl2(E-iminoetherú2]. A concept for activation of the trans geometry in platinum antitumor complexes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F03%3A00032356" target="_blank" >RIV/68081707:_____/03:00032356 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    DNA-protein cross-linking by trans-[PtCl2(E-iminoetherú2]. A concept for activation of the trans geometry in platinum antitumor complexes

  • Original language description

    Interactions of DNA with antitumor trans-[PtCl2(E-iminoether)2] were investigated using the methods of molecular biophysics. It has been found that unexpected antitumor effects of this complex are associated with its capability to form DNA-protein cross-links.

  • Czech name

    Tvorba mustků mezi DNA a proteiny komplexem trans-[PtCl2(E-iminoether)]

  • Czech description

    Byly studovány interakce DNA s novým protinádorově účinným komplexem trans-[PtCl2(E-iminoether)2] metodami molekulární biofyziky. Bylo zjištěno, že za neočekávané protinádorové účinky tohoto komplexu jsou zodpovědné můstky, které tato platinová sloučenina vytváří mezi DNA a proteiny.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2003

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nucleic Acids Research

  • ISSN

    0305-1048

  • e-ISSN

  • Volume of the periodical

    31

  • Issue of the periodical within the volume

    22

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    11

  • Pages from-to

    6450-6460

  • UT code for WoS article

  • EID of the result in the Scopus database