Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F03%3A17033054" target="_blank" >RIV/68081707:_____/03:17033054 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand.
Original language description
We examined oligodeoxyribonucleotide duplexes bearing a site-specific cross-link of the transplatin analogue containing the piperidine ligand.The results indicate that in contrast to transplatin, trans-[PtCl2(NH3)(piperidine)] forms stable 1,3-intrastrand cross-links in double-helical DNA that distort DNAand are not readily removed fromDNAby nucleotide excision repair system. Hence, the intrastrand cross-linksof trans-(PtCl2(NH3)(piperidine)) could persist for a sufficiently long time, potentiating itstoxicity toward tumor cells. trans-[PtCl2(NH3)(piperidine)] also forms in DNA minor interstrand cross-links that are similar to those of transplatin so that these adducts appear less likely candidates for genotoxic lesion responsible for antitumor effects of trans-[PtCl2(NH3)(piperidine)]. Hence, the role of structurally unique intrastrand cross-links in the antitumor effects of transplatin analogues in which one ammine group is replaced by a heterocyclic ligand may predominate.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Chemistry
ISSN
0021-9258
e-ISSN
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Volume of the periodical
278
Issue of the periodical within the volume
48
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
47516-47525
UT code for WoS article
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EID of the result in the Scopus database
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