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Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F05%3A00001076" target="_blank" >RIV/68081707:_____/05:00001076 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis

  • Original language description

    Pre-treatment of colon adenocarcinoma HT-29 cells with arachidonic or docosahexaenoic fatty acids which induced oxidative stress sensitized these cells to apoptosis induced by TNF-alpha or anti-Fas monoclonal antibody. The higher amount of floating cells, subG0/G1 population and apoptotic cells detected in pre-treated cells was potentiated by inhibition of protein synthesis by cycloheximide.

  • Czech name

    Interakce vysoce nenasycených mastných kyselin a butyrátu sodného během apoptózy buněk lidského adenokarcinomu kolonu HT-29

  • Czech description

    Ovlivnění buněk lidského adenokarcinomu kolonu HT-29 mastnými kyselinami arachidonovou nebo dokosahexaenovou zvyšujícími oxidativní stres zcitlivovalo tyto buňky k apoptóze indukované TNF-alpha nebo anti-Fas monoklonální protilátkou. Zvýšené množství plovoucích buněk, buněk v subG0/G1 fázi i buněk s apoptickou morfologií u kyselinami ovlivněné populace bylo posíleno inhibicí syntézy proteinů cykloheximidem.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA524%2F04%2F0895" target="_blank" >GA524/04/0895: Mechanisms of the cell death induced by dietary lipid components and endogenous apoptotic regulators in colon epithelial cells</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cancer letters

  • ISSN

    0304-3835

  • e-ISSN

  • Volume of the periodical

    218

  • Issue of the periodical within the volume

    -

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    9

  • Pages from-to

    33-41

  • UT code for WoS article

  • EID of the result in the Scopus database