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Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F05%3A00026056" target="_blank" >RIV/68081707:_____/05:00026056 - isvavai.cz</a>

  • Alternative codes found

    RIV/00209805:_____/05:0000040 RIV/00209805:_____/05:0000032

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines

  • Original language description

    In this work we have shown that expression of SOCS3 gene was stimulated by interferon gamma in most human melanoma cell lines while interferon alpha was largely inefficient in induction of this gene. The data suggest that melanoma cells might have altered responses to interferon alpha compared to normal melanocytes.

  • Czech name

    Indukce exprese genu SOCS3 po interferonu gama (ale ne alfa) v buněčných liniích maligního melanomu

  • Czech description

    V této práci jsme zjistili, že ve většině melanomových linií dochází k induikci genu SOCS3 po působení interferonu gama, nikoliv však interferonu alfa. Tento výsledek naznačuje, že signální dráhy indukující expresi SOCS3 interferonem alfa mohou být v melanomových buňkách porušeny.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Melanoma Research

  • ISSN

    0960-8931

  • e-ISSN

  • Volume of the periodical

    15

  • Issue of the periodical within the volume

    -

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    481-488

  • UT code for WoS article

  • EID of the result in the Scopus database