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Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F06%3A00047034" target="_blank" >RIV/68081707:_____/06:00047034 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells

  • Original language description

    We showed that TRAIL-induced apoptosis may be differentially regulated by inhibitors of MEK/ERK (U0126) or PI3K/Akt (LY294002) pathway in TRAIL-sensitive (HT-29) and TRAIL-resistant (SW620) human epithelial colon cancer cells, and suggested the mechanisms involved.

  • Czech name

    Modulace apoptózy indukované TRAILem prostřednictvím inhibice signálních drah pro přežití závisí na citlivosti/rezistenci nádorových buněk kolonu k účinkům TRAILu

  • Czech description

    Ukázali jsme, že apoptózu indukovanou TRAILem lze rozdílně modulovat pomocí inhibitorů drah MEK/ERK (U0126) nebo PI3K/Akt (LY294002) u nádorových buněk kolonu citlivých (Ht-29) a rezistentních (SW620) k účinkům tohoto cytokinu, a navrhli jsme možné mechanismy.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    FEBS Letters

  • ISSN

    0014-5793

  • e-ISSN

  • Volume of the periodical

    580

  • Issue of the periodical within the volume

    28-29

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    5

  • Pages from-to

    6565-6569

  • UT code for WoS article

  • EID of the result in the Scopus database