Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F09%3A00329490" target="_blank" >RIV/68081707:_____/09:00329490 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells

Original language description

We have examined activity of 12 Pt(II)-based DNA intercalators of the type [Pt(IL)(AL)]2+, where IL is an intercalating ligand (1,10-phenanthroline or a methylated derivative) and AL is an ancillary ligand (diaminocyclohexane, diphenylethylenediamine or1,2-bis(4-fluorophenyl)-1,2-ethylenediamine) against a panel of human cancer cell lines and further in vitro testing was conducted to provide information about the mechanism of action.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

AQ - Safety and health protection, safety in operating machinery

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Medicinal Chemistry

ISSN

0022-2623

e-ISSN

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Volume of the periodical

52

Issue of the periodical within the volume

17

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

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UT code for WoS article

000269655500020

EID of the result in the Scopus database

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