The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F11%3A00358792" target="_blank" >RIV/68081707:_____/11:00358792 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.tiv.2010.10.006" target="_blank" >http://dx.doi.org/10.1016/j.tiv.2010.10.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tiv.2010.10.006" target="_blank" >10.1016/j.tiv.2010.10.006</a>

Result language

angličtina

Original language name

The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages

Original language description

The aim of the present study was to investigate the effects of lipid peroxidation products (LPPs) - acrolein, 4-hydroxynonenal, and malondialdehyde - on ROS and NO production in RAW 264.7 macrophages. Our study shows that the cytotoxic action of acroleinand 4-hydroxynonenal works in a dose- and timedependent manner. Moreover, LPPs can inhibit ROS and NO production partially independently of their toxic effect. Changes in enzymatic pathways and NO scavenging properties are included in the downregulationof reactive species formation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology in Vitro

ISSN

0887-2333

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

145-152

UT code for WoS article

000287010600019

EID of the result in the Scopus database

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