All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Preferential binding of IFI16 protein to cruciform structure and superhelical DNA

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F12%3A00379230" target="_blank" >RIV/68081707:_____/12:00379230 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.bbrc.2012.05.065" target="_blank" >http://dx.doi.org/10.1016/j.bbrc.2012.05.065</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.bbrc.2012.05.065" target="_blank" >10.1016/j.bbrc.2012.05.065</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Preferential binding of IFI16 protein to cruciform structure and superhelical DNA

  • Original language description

    Interferon (IFN)-inducible HIN-200 proteins play an important role in transcriptional regulation linked to cell cycle control, inflammation, autoimmunity and differentiation. We demonstrate that IFI16 protein binds strongly to negatively superhelical plasmid DNA. We also detect a strong preference for IFI16 binding to cruciform DNA structure compared to linear DNA topology. This novel DNA-binding property of IFI16 protein to scDNA and cruciform structures may play critical roles in its tumor suppressorfunction.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GAP301%2F10%2F1211" target="_blank" >GAP301/10/1211: Transcriptional activities of wild-type and mutant p53, decision between cell proliferation, cell cycle arrest and apoptosis</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochemical and Biophysical Research Communications

  • ISSN

    0006-291X

  • e-ISSN

  • Volume of the periodical

    422

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    5

  • Pages from-to

    716-720

  • UT code for WoS article

    000306443900033

  • EID of the result in the Scopus database