Role of histamine receptors in the effects of histamine on the production of reactive oxygen species by whole blood phagocytes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F14%3A00428666" target="_blank" >RIV/68081707:_____/14:00428666 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.lfs.2014.01.082" target="_blank" >http://dx.doi.org/10.1016/j.lfs.2014.01.082</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.lfs.2014.01.082" target="_blank" >10.1016/j.lfs.2014.01.082</a>

Result language

angličtina

Original language name

Role of histamine receptors in the effects of histamine on the production of reactive oxygen species by whole blood phagocytes

Original language description

Aims: The diverse physiological functions of histamine are mediated through distinct histamine receptors. In this study we investigated the role of H2R and H4R in the effects of histamine on the production of reactive oxygen species by phagocytes in whole blood. Main methods: Changes in reactive oxygen species (ROS) production by whole blood phagocytes after treatment with histamine, H4R agonists (4-methylhistamine, VUF8430), H2R agonist (dimaprit) and their combinations with H4R antagonist (JNJ10191584) and H2R antagonist (ranitidine) were determined using the chemiluminescence (CL) assay. To exclude the direct scavenging effects of the studied compounds on the CL response, the antioxidant properties of all compounds were measured using several methods (TRAP, ORAC, and luminol-HRP-H2O2 based CL). Key findings: Histamine, 4-methylhistamine, VUF8430 and dimaprit inhibited the spontaneous and OZP-activated whole blood CL in a dose-dependent manner.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/LD11010" target="_blank" >LD11010: The effects of histamine receptor H4R antagonists on the production of reactive oxygen and nitrogen metabolites by phagocytes</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Life Sciences

ISSN

0024-3205

e-ISSN

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Volume of the periodical

100

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

67-72

UT code for WoS article

000334323600009

EID of the result in the Scopus database

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