Ultrastructure of Cytoplasmic and Nuclear Inosine-5 '-Monophosphate Dehydrogenase 2 "Rods and Rings" Inclusions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F14%3A00435172" target="_blank" >RIV/68081707:_____/14:00435172 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/14:00440593
Result on the web
<a href="http://dx.doi.org/10.1369/0022155414543853" target="_blank" >http://dx.doi.org/10.1369/0022155414543853</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1369/0022155414543853" target="_blank" >10.1369/0022155414543853</a>

Result language
angličtina
Original language name
Ultrastructure of Cytoplasmic and Nuclear Inosine-5 '-Monophosphate Dehydrogenase 2 "Rods and Rings" Inclusions
Original language description
Inosine-5-monophosphate dehydrogenase catalyzes the critical step in the de novo synthesis of guanosine nucleotides: the oxidation of inosine monophosphate to xanthosine monophosphate. This reaction can be inhibited by specific inhibitors, such as ribavirin or mycophenolic acid, which are widely used in clinical treatment when required to inhibit the proliferation of viruses or cells. However, it was recently found that such an inhibition affects the cells, leading to a redistribution of IMPDH2 and theappearance of IMPDH2 inclusions in the cytoplasm. According to their shape, these inclusions have been termed Rods and Rings (R&R). In this work, we focused on the subcellular localization of IMPDH2 protein and the ultrastructure of R&R inclusions. Usingmicroscopy and western blot analysis, we show the presence of nuclear IMPDH2 in human cells.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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