Frequent Chromatin Rearrangements in Myelodysplastic Syndromes - What Stands Behind?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F14%3A00435477" target="_blank" >RIV/68081707:_____/14:00435477 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/14:10285723 RIV/00064165:_____/14:10285723 RIV/00023736:_____/14:00011128

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Frequent Chromatin Rearrangements in Myelodysplastic Syndromes - What Stands Behind?

Original language description

Myelodysplastic syndromes (MDS) represent a clinically and genetically heterogeneous group of clonal haematopoietic diseases characterized by a short survival and high rate of transformation to acute myeloid leukaemia (AML). In spite of this variability,MDS is associated with typical recurrent non-random cytogenetic defects. Chromosomal abnormalities are detected in the malignant bone-marrow cells of approximately 40-80 % of patients with primary or secondary MDS. The most frequent chromosomal rearrangements involve chromosomes 5, 7 and 8. MDS often shows presence of unbalanced chromosomal changes, especially large deletions [del(5), del(7q), del(12p), del(18q), del(20q)] or losses of whole chromosomes (7 and Y). The most typical cytogenetic abnormality is a partial or complete deletion of 5q- that occurs in roughly 30 % of all MDS cases either as the sole abnormality or in combination with other aberrations as a part of frequently complex karyotypes. The mechanisms responsible for th

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

2014

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

1-7

UT code for WoS article

000343275800001

EID of the result in the Scopus database

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