Dishevelled at the Crossroads of Pathways
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F14%3A00506830" target="_blank" >RIV/68081707:_____/14:00506830 - isvavai.cz</a>
Result on the web
<a href="http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3407699&blobtype=pdf" target="_blank" >http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3407699&blobtype=pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/2045-3701-2-14" target="_blank" >10.1186/2045-3701-2-14</a>
Alternative languages
Result language
angličtina
Original language name
Dishevelled at the Crossroads of Pathways
Original language description
Cell signaling mediated by morphogens is essential to coordinate growth and patterning, two key processes thatngovern the formation of a complex multi-cellular organism. During growth and patterning, cells are specified bynboth quantitative and directional information. While quantitative information regulates cell proliferation andndifferentiation, directional information is conveyed in the form of cell polarities instructed by local and global cues.nMajor morphogens like Wnts play critical roles in embryonic development and they are also important innmaintaining tissue homeostasis. Abnormal regulation of these signaling events leads to a diverse array ofndevastating diseases including cancer. Wnts transduce their signals through several distinct pathways and theynregulate vertebrate embryonic development by providing both quantitative and directional information. Here,ntaking the developing skeletal system as an example, we review our work on Wnt signaling pathways in variousnaspects of development. We focus particularly on our most recent findings that showed that in vertebrates, Wnt5anacts as a global cue to establishing planar cell polarity (PCP). Our work suggests that Wnt morphogens regulatendevelopment by integrating quantitative and directional information. Our work also provides important insights inndisease like Robinow syndrome, brachydactyly type B1 (BDB1) and spina bifida, which can be caused by humannmutations in the Wnt/PCP signaling pathwa.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
WNT SIGNALING IN DEVELOPMENT AND DISEASE: MOLECULAR MECHANISMS AND BIOLOGICAL FUNCTIONS
ISBN
978-1-118-44409-2
Number of pages of the result
10
Pages from-to
—
Number of pages of the book
459
Publisher name
JOHN WILEY & SONS INC
Place of publication
HOBOKEN
UT code for WoS chapter
000348498000018