Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F15%3A00452062" target="_blank" >RIV/68081707:_____/15:00452062 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/15:10314407 RIV/00216224:14310/15:00095868

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pone.0141020" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0141020</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0141020" target="_blank" >10.1371/journal.pone.0141020</a>

Result language

angličtina

Original language name

Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells

Original language description

We demonstrated for the first time an outstanding ability of rosiglitazone to mediate a profound enhancement of LA-12-induced apoptosis associated with activation of mitochondrial pathway in human colon cancer cells. This effect was preferentially observed in the G1 cell cycle phase, independent on p53 and PPAR. proteins, and accompanied with significant changes of selected Bcl-2 family protein levels. Further stimulation of cooperative synergic cytotoxic action of rosiglitazone and LA-12 was demonstrated in the cells deficient for PTEN, where mitochondrial apoptotic pathway was more stimulated and G1-phase-associated dying was reinforced. Our results suggest that combined treatment with rosiglitazone and LA-12 might be promising anticancer strategy incolon-derived tumours regardless of their p53 status, and also favourable in those defective in PTEN function.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/GA15-06650S" target="_blank" >GA15-06650S: Novel molecular mechanisms involved in chemotherapeutic drug- and cytokine-induced cancer cell death</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS ONE

ISSN

1932-6203

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

10

Country of publishing house

US - UNITED STATES

Number of pages

20

Pages from-to

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UT code for WoS article

000363249300023

EID of the result in the Scopus database

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