Inhibition of beta-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F15%3A00456480" target="_blank" >RIV/68081707:_____/15:00456480 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/15:00456480 RIV/00027162:_____/15:#0001341 RIV/00216224:14310/15:00095774
Result on the web
<a href="http://dx.doi.org/10.1093/mutage/gev019" target="_blank" >http://dx.doi.org/10.1093/mutage/gev019</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/mutage/gev019" target="_blank" >10.1093/mutage/gev019</a>

Result language
angličtina
Original language name
Inhibition of beta-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation
Original language description
Deregulation of Wnt/beta-catenin signalling plays an important role in the pathogenesis of colorectal cancer. Interestingly, this pathway has been recently implicated in transcriptional control of cytochrome P450 (CYP) family 1 enzymes, which are responsible for bioactivation of a number of dietary carcinogens. In the present study, we investigated the impact of inhibition of Wnt/beta-catenin pathway on metabolism and genotoxicity of benzo[a]pyrene (BaP), a highly mutagenic polycyclic aromatic hydrocarbon and an efficient ligand of the aryl hydrocarbon receptor, which is known as a primary regulator of CYP1 expression, in cellular models derived from colorectal tumours. We observed that a synthetic inhibitor of beta-catenin, JW74, significantly increased formation of BaP-induced DNA adducts in both colorectal adenoma and carcinoma-derived cell lines. Using the short interfering RNA (siRNA) targeting beta-catenin, we then found that beta-catenin knockdown in HCT116 colon carcinoma cells
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—

Project
<a href="/en/project/GA13-09766S" target="_blank" >GA13-09766S: Lipid nutritional factors as modulators of xenobiotic metabolism and toxicity in colon epithelial cells</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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