Influence of serum albumin on intracellular delivery of drug-loaded hyaluronan polymeric micelles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00463781" target="_blank" >RIV/68081707:_____/16:00463781 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/16:00065501 RIV/00216224:14310/16:00095864
Result on the web
<a href="http://dx.doi.org/10.1016/j.ijpharm.2016.07.057" target="_blank" >http://dx.doi.org/10.1016/j.ijpharm.2016.07.057</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2016.07.057" target="_blank" >10.1016/j.ijpharm.2016.07.057</a>

Result language
angličtina
Original language name
Influence of serum albumin on intracellular delivery of drug-loaded hyaluronan polymeric micelles
Original language description
Polymeric micelles are attractive drug delivery systems for intravenously administered nonpolar drugs. Although physical parameters like size, shape and loading capacity are considered as the most important for their efficiency, here we demonstrate that the effects of serum protein interaction and characteristics of loaded compound cannot be neglected during the micelle development and design of experimental set up. Polymeric micelles prepared from amphiphilic hyaluronic acid grafted with short (hexanoic) and long fatty acids (oleic) were tested after loading with two different hydrophobic models, Nile red and curcumin. The composition of micelles affected mainly the loading capacity. Both encapsulated compounds behaved differently in the in vitro cell uptake, which was also influenced by serum concentration, where serum albumin was found to be the primary destabilizing component. This destabilization was found to be influenced by polymeric micelle concentration. Thus, the chemical structure of micelle, the properties of non-covalently loaded substance and serum albumin/polymeric micelle ratio modulate the in vitro intracellular uptake of drugs loaded in nanocarriers. (C) 2016 Published by Elsevier B.V.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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