The evolutionary pathway of the staphylococcal cassette chromosome element

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00471943" target="_blank" >RIV/68081707:_____/16:00471943 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/16:00088536
Result on the web
<a href="http://dx.doi.org/10.1515/biolog-2016-0156" target="_blank" >http://dx.doi.org/10.1515/biolog-2016-0156</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/biolog-2016-0156" target="_blank" >10.1515/biolog-2016-0156</a>

Result language
angličtina
Original language name
The evolutionary pathway of the staphylococcal cassette chromosome element
Original language description
The staphylococcal cassette chromosome (SCC) element can carry resistance genes to antibiotics, disinfectants, and heavy metals, contributing to the survival of strains in the environment and causing difficulties in the treatment of staphylococcal infections. Methicillin resistance in staphylococci, which is of particular clinical significance, is encoded by staphylococcal cassette chromosome mec (SCCmec). Despite the importance of the SCC element and description of multiple nucleotide sequences, the information about its origin and evolution is still scarce. Here, we present a phylogenetic analysis of SCC elements that is unique in the use of whole SCC sequences. A phylogenetic tree for a noteworthy number of 81 SCC elements based on global sequence alignment was constructed. The SCC clustering did not reflect the genetic relationships of bacteria containing the SCC elements, but was done according to type, determined by the combination of mec gene complex class and ccr gene complex type. The results emphasise the horizontal gene transfer as a means of spread of SCC elements in bacterial strains. Overall, this study contributes to the understanding of SCC emergence, evolution, and dissemination.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—

Project
<a href="/en/project/GP13-05069P" target="_blank" >GP13-05069P: Horizontal transfer of Staphylococcal Cassette Chromosome mec (SCCmec) elements mediated by bacteriophages across the Staphylococcus strains</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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