Strong preference of BRCA1 protein to topologically constrained non-B DNA structures

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00471968" target="_blank" >RIV/68081707:_____/16:00471968 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/s12867-016-0068-6" target="_blank" >http://dx.doi.org/10.1186/s12867-016-0068-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12867-016-0068-6" target="_blank" >10.1186/s12867-016-0068-6</a>

Result language
angličtina
Original language name
Strong preference of BRCA1 protein to topologically constrained non-B DNA structures
Original language description
Background: The breast and ovarian cancer susceptibility gene BRCA1 encodes a multifunctional tumor suppressor protein BRCA1, which is involved in regulating cellular processes such as cell cycle, transcription, DNA repair, DNA damage response and chromatin remodeling. BRCA1 protein, located primarily in cell nuclei, interacts with multiple proteins and various DNA targets. It has been demonstrated that BRCA1 protein binds to damaged DNA and plays a role in the transcriptional regulation of downstream target genes. As a key protein in the repair of DNA double-strand breaks, the BRCA1-DNA binding properties, however, have not been reported in detail.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—

Project
<a href="/en/project/GA15-21855S" target="_blank" >GA15-21855S: Influence of conformation motifs and epigenetic modifications to DNA binding properties of p53 family proteins</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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