Effect of gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00472015" target="_blank" >RIV/68081707:_____/16:00472015 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/s12951-016-0215-8" target="_blank" >http://dx.doi.org/10.1186/s12951-016-0215-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12951-016-0215-8" target="_blank" >10.1186/s12951-016-0215-8</a>
Alternative languages
Result language
angličtina
Original language name
Effect of gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cells
Original language description
Background: Tumor targeting of radiotherapy represents a great challenge. The addition of multimodal nanoparticles, such as 3 nm gadolinium-based nanoparticles (GdBNs), has been proposed as a promising strategy to amplify the effects of radiation in tumors and improve diagnostics using the same agents. This singular property named theranostic is a unique advantage of GdBNs. It has been established that the amplification of radiation effects by GdBNs appears due to fast electronic processes. However, the influence of these nanoparticles on cells is not yet understood. In particular, it remains dubious how nanoparticles activated by ionizing radiation interact with cells and their constituents. A crucial question remains open of whether damage to the nucleus is necessary for the radiosensitization exerted by GdBNs (and other nanoparticles).
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GBP302%2F12%2FG157" target="_blank" >GBP302/12/G157: Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Nanobiotechnology
ISSN
1477-3155
e-ISSN
—
Volume of the periodical
14
Issue of the periodical within the volume
JUL2016
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
—
UT code for WoS article
000381674400002
EID of the result in the Scopus database
—