Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F17%3A00476269" target="_blank" >RIV/68081707:_____/17:00476269 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/17:73583747

Result on the web

<a href="http://dx.doi.org/10.1039/c7mt00052a" target="_blank" >http://dx.doi.org/10.1039/c7mt00052a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c7mt00052a" target="_blank" >10.1039/c7mt00052a</a>

Result language

angličtina

Original language name

Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex

Original language description

The DNA interstrand cross-links of the antitumor drug {[cis-Pt(NH3)(2)Cl](2)(4,4'-methylenedianiline)}(2+) (1) play a prevalent role in its antitumor effects. Complex 1 forms DNA long-range interstrand cross-links uniquely in the 3'-3' direction. Conformational distortions induced by these interstrand cross-links in DNA represent a potential structural motif for recognition by high-mobility-group proteins.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Metallomics

ISSN

1756-5901

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

494-500

UT code for WoS article

000402049600007

EID of the result in the Scopus database

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