Nonenzymatic Oligomerization of 3 ',5 '-Cyclic CMP Induced by Proton and UV Irradiation Hints at a Nonfastidious Origin of RNA

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F17%3A00485600" target="_blank" >RIV/68081707:_____/17:00485600 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/17:73584445

Result on the web

<a href="http://dx.doi.org/10.1002/cbic.201700122" target="_blank" >http://dx.doi.org/10.1002/cbic.201700122</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cbic.201700122" target="_blank" >10.1002/cbic.201700122</a>

Result language

angličtina

Original language name

Nonenzymatic Oligomerization of 3 ',5 '-Cyclic CMP Induced by Proton and UV Irradiation Hints at a Nonfastidious Origin of RNA

Original language description

We report that 3',5'-cyclic CMP undergoes nonenzymatic diand trimerization at 20 degrees C under dry conditions upon proton or UV irradiation. The reaction involves stacking of the cyclic monomers and subsequent polymerization through serial transphosphorylations between the stacked monomers. Proton-and UV-induced oligomerization of 3',5'-cyclic CMP demonstrates that pyrimidines-similar to purines-might also have taken part in the spontaneous generation of RNA under plausible prebiotic conditions as well as in an extraterrestrial context. The observed polymerization of naturally occurring 3',5'-cyclic nucleotides supports the possibility that the extant genetic nucleic acids might have originated by way of a straight Occamian path, starting from simple reactions between plausibly preactivated monomers.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chembiochem

ISSN

1439-4227

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

15

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

1535-1543

UT code for WoS article

000406932800013

EID of the result in the Scopus database

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