Cytotoxic platinum coordination compounds. DNA binding agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F17%3A00486105" target="_blank" >RIV/68081707:_____/17:00486105 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/17:73583738
Result on the web
<a href="http://dx.doi.org/10.1016/j.ccr.2017.04.013" target="_blank" >http://dx.doi.org/10.1016/j.ccr.2017.04.013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ccr.2017.04.013" target="_blank" >10.1016/j.ccr.2017.04.013</a>
Alternative languages
Result language
angličtina
Original language name
Cytotoxic platinum coordination compounds. DNA binding agents
Original language description
Despite the widespread use of antineoplastic platinum drugs, a number of accompanying disadvantages exist. In connection with attempts to circumvent these problems, new platinum compounds have been prepared and mechanisms underlying their biological activity have been extensively investigated. These mechanistic investigations involve research focused on understanding interactions of platinum agents with DNA since DNA binding and recognition of DNA modified by these metallodrugs are the important processes responsible for their anticancer properties. In this review, we discuss how various classes of platinum(II) complexes, which can interact with DNA by coordination, intercalation and other noncovalent modes of binding or by a combination of these DNA binding modes, can alter the cellular response induced by conventional platinum drugs. We describe that these alterations can be achieved by changing: (i) the nature and structure of the DNA lesion induced (ii) conformational alterations induced in DNA by these lesions, and (iii) various cellular signaling pathways initiated by platinum DNA damage. We anticipate that summarization of the results on DNA binding of cytotoxic platinum compounds may help to shed light on their potency and will make it possible to create new strategies to design rationally new anticancer platinum compounds and/or combine platinum drugs with other cytotoxic agents. (C) 2017 Elsevier B.V. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA17-09436S" target="_blank" >GA17-09436S: Translesion DNA synthesis across lesions induced by agents of biological significance. An insight into energetics, kinetics and mechanism</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Coordination Chemistry Reviews
ISSN
0010-8545
e-ISSN
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Volume of the periodical
351
Issue of the periodical within the volume
2017
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
30
Pages from-to
2-31
UT code for WoS article
000415777700002
EID of the result in the Scopus database
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