Electrophilic Nitro-Fatty Acids: Nitric Oxide and Nitrite-Derived Metabolic and Inflammatory Signaling Mediators
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F17%3A00532857" target="_blank" >RIV/68081707:_____/17:00532857 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/B9780128042731000168" target="_blank" >https://www.sciencedirect.com/science/article/pii/B9780128042731000168</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-804273-1.00016-8" target="_blank" >10.1016/B978-0-12-804273-1.00016-8</a>
Alternative languages
Result language
angličtina
Original language name
Electrophilic Nitro-Fatty Acids: Nitric Oxide and Nitrite-Derived Metabolic and Inflammatory Signaling Mediators
Original language description
The modification of cell proteins by metabolically and environmentally induced redox reactions significantly expands the functional proteome. These posttranslational modifications (PTMs) of proteins allow cells to dynamically regulate metabolism, growth, differentiation, and immune responses. In particular, PTMs continue to emerge as a critical component of nitric oxide (NO) and “redox” signaling. In addition to its role in activating guanylate cyclase via heme-iron coordination, NO reacts with superoxide and lipid radicals and is further oxidized by metalloproteins to yield some of the most reactive molecules in biology. These reactions yield secondary nitrogen oxides, such as nitrogen dioxide, that expand the breadth of reactions transducing redox-dependent signaling responses. One class of by-products, unsaturated fatty acid nitroalkene derivatives (nitro-fatty acids), is electrophilic and induces PTMs by reversible Michael addition of protein thiols. Since multiple transcriptional regulatory mechanisms have protein constituents with functionally significant electrophile-reactive amino acids, this represents a population of nitro-fatty acid–responsive protein targets. This highly conserved property provides cells with a capability to undergo stress-related adaptive gene expression and signaling reactions, in response to increased levels of lipid electrophile generation. This chapter reviews model system and clinical data regarding the mechanisms of formation of electrophilic nitro-fatty acid derivatives and their antiinflammatory actions in model systems and FDA-approved clinical trials. The molecular targets, shifts in gene transcription patterns, cell signaling reactions, and physiological responses induced by low concentrations of electrophilic nitro-fatty acids reveal that these mediators are nontoxic and mediate antiinflammatory and adaptive signaling responses.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
—
OECD FORD branch
10601 - Cell biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
NITRIC OXIDE: BIOLOGY AND PATHOBIOLOGY, 3RD EDITION
ISBN
978-0-12-804319-6
Number of pages of the result
17
Pages from-to
213-229
Number of pages of the book
434
Publisher name
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Place of publication
24-28 OVAL ROAD, LONDON NW1 7DX, ENGLAND
UT code for WoS chapter
000416951800017