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Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F18%3A00488378" target="_blank" >RIV/68081707:_____/18:00488378 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14310/18:00100761 RIV/00159816:_____/18:00067441

  • Result on the web

    <a href="http://dx.doi.org/10.1038/onc.2017.392" target="_blank" >http://dx.doi.org/10.1038/onc.2017.392</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/onc.2017.392" target="_blank" >10.1038/onc.2017.392</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding

  • Original language description

    Metastasis accounts for most of cancer-related deaths. Paracrine signaling between tumor cells and the stroma induces changes in the tumor microenvironment required for metastasis. Transcription factor c-Myb was associated with breast cancer (BC) progression but its role in metastasis remains unclear. Here we show that increased c-Myb expression in BC cells inhibits spontaneous lung metastasis through impaired tumor cell extravasation. On contrary, BC cells with increased lung metastatic capacity exhibited low c-Myb levels. We identified a specific inflammatory signature, including Ccl2 chemokine, that was expressed in lung metastatic cells but was suppressed in tumor cells with higher c-Myb levels. Tumor cell-derived Ccl2 expression facilitated lung metastasis and rescued trans-endothelial migration of c-Myb overexpressing cells. Clinical data show that the identified inflammatory signature, together with a MYB expression, predicts lung metastasis relapse in BC patients. These results demonstrate that the c-Myb-regulated transcriptional program in BCs results in a blunted inflammatory response and consequently suppresses lung metastasis.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Oncogene

  • ISSN

    0950-9232

  • e-ISSN

  • Volume of the periodical

    37

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    11

  • Pages from-to

    1020-1030

  • UT code for WoS article

    000425905700005

  • EID of the result in the Scopus database