Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F18%3A00488378" target="_blank" >RIV/68081707:_____/18:00488378 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/18:00100761 RIV/00159816:_____/18:00067441

Result on the web

<a href="http://dx.doi.org/10.1038/onc.2017.392" target="_blank" >http://dx.doi.org/10.1038/onc.2017.392</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/onc.2017.392" target="_blank" >10.1038/onc.2017.392</a>

Result language

angličtina

Original language name

Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding

Original language description

Metastasis accounts for most of cancer-related deaths. Paracrine signaling between tumor cells and the stroma induces changes in the tumor microenvironment required for metastasis. Transcription factor c-Myb was associated with breast cancer (BC) progression but its role in metastasis remains unclear. Here we show that increased c-Myb expression in BC cells inhibits spontaneous lung metastasis through impaired tumor cell extravasation. On contrary, BC cells with increased lung metastatic capacity exhibited low c-Myb levels. We identified a specific inflammatory signature, including Ccl2 chemokine, that was expressed in lung metastatic cells but was suppressed in tumor cells with higher c-Myb levels. Tumor cell-derived Ccl2 expression facilitated lung metastasis and rescued trans-endothelial migration of c-Myb overexpressing cells. Clinical data show that the identified inflammatory signature, together with a MYB expression, predicts lung metastasis relapse in BC patients. These results demonstrate that the c-Myb-regulated transcriptional program in BCs results in a blunted inflammatory response and consequently suppresses lung metastasis.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncogene

ISSN

0950-9232

e-ISSN

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Volume of the periodical

37

Issue of the periodical within the volume

8

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1020-1030

UT code for WoS article

000425905700005

EID of the result in the Scopus database

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