Printing inks of electroactive polymer PEDOT:PSS: The study of biocompatibility, stability, and electrical properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F18%3A00492424" target="_blank" >RIV/68081707:_____/18:00492424 - isvavai.cz</a>
Alternative codes found
RIV/28778758:_____/18:N0000001 RIV/00216305:26310/18:PU127100 RIV/00216224:14310/18:00102402 RIV/00159816:_____/18:00068624
Result on the web
<a href="http://dx.doi.org/10.1002/jbm.a.36314" target="_blank" >http://dx.doi.org/10.1002/jbm.a.36314</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jbm.a.36314" target="_blank" >10.1002/jbm.a.36314</a>
Alternative languages
Result language
angličtina
Original language name
Printing inks of electroactive polymer PEDOT:PSS: The study of biocompatibility, stability, and electrical properties
Original language description
Biocompatibility tests and a study of the electrical properties of thin films prepared from six electroactive polymer ink formulations based on poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) were performed. The aim was to find a suitable formulation of PEDOT:PSS and conditions for preparing thin films in order to construct printed bioelectronic devices for biomedical applications. The stability and electrical properties of such films were tested on organic electrochemical transistor (OECT)-based sensor platforms and their biocompatibility was evaluated in assays with 3T3 fibroblasts and murine cardiomyocytes. It was found that the thin films prepared from inks without an additive or any thin film post-treatment provide limited conductivity and stability for use in biomedical applications. These properties were greatly improved by using ethylene glycol and thermal annealing. Addition or post-treatment by ethylene glycol in combination with thermal annealing provided thin films with electrical resistance and a stability sufficient to be used in sensing of animal cell physiology. These films coated with collagen IV showed good biocompatibility in the assay with 3T3 fibroblasts when compared to standard cell culture plastics. Selected films were then used in assays with murine cardiomyocytes. We observed that these cells were able to attach to the PEDOT:PSS films and form an active sensor element. Spontaneously beating clusters were formed, indicating a good physiological status for the cardiomyocyte cells. These results open the door to construction of cheap printed electronic devices for biointerfacing in biomedical applications. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1121-1128, 2018.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biomedical Materials Research. Part A
ISSN
1549-3296
e-ISSN
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Volume of the periodical
106
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1121-1128
UT code for WoS article
000426512100025
EID of the result in the Scopus database
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