Polynuclear Platinum Complexes. Structural Diversity and DNA Binding
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F18%3A00535937" target="_blank" >RIV/68081707:_____/18:00535937 - isvavai.cz</a>
Result on the web
<a href="https://www.degruyter.com/view/title/518384" target="_blank" >https://www.degruyter.com/view/title/518384</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/9783110470734-002" target="_blank" >10.1515/9783110470734-002</a>
Alternative languages
Result language
angličtina
Original language name
Polynuclear Platinum Complexes. Structural Diversity and DNA Binding
Original language description
Polynuclear platinum complexes (PPCs) represent a discrete structural class of DNA-binding agents with excellent antitumor properties. The use of at least two platinum coordinating units automatically means that multifunctional DNA binding modes are possible. The structural variability inherent in a polynuclear platinum structure can be harnessed to produce discrete modes of DNA binding, with conformational changes distinct from and indeed inaccessible to, the mononuclear agents such as cisplatin. Since our original contributions in this field a wide variety of dinuclear complexes especially have been prepared, their DNA binding studied, and potential relevance to cytotoxicity examined. This chapter focuses on how DNA structure and reactivity is modulated through interactions with PPCs with emphasis on novel aspects of such structure and reactivity. How these major changes are further reflected in damaged DNA-protein binding and cellular effects are reviewed. We further review, for the first time, the great structural diversity achieved in PPC complex design and summarize their major DNA binding effects.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
METALLO-DRUGS: DEVELOPMENT AND ACTION OF ANTICANCER AGENTS
ISSN
1559-0836
e-ISSN
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Volume of the periodical
18
Issue of the periodical within the volume
2018
Country of publishing house
DE - GERMANY
Number of pages
26
Pages from-to
43-68
UT code for WoS article
000471131700004
EID of the result in the Scopus database
2-s2.0-85049287331