New half-sandwich ruthenium(ii) complexes as proteosynthesis inhibitors in cancer cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F19%3A00503100" target="_blank" >RIV/68081707:_____/19:00503100 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/c8cc09211g" target="_blank" >http://dx.doi.org/10.1039/c8cc09211g</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c8cc09211g" target="_blank" >10.1039/c8cc09211g</a>

Result language
angličtina
Original language name
New half-sandwich ruthenium(ii) complexes as proteosynthesis inhibitors in cancer cells
Original language description
Half-sandwich ruthenium(ii) complexes [((6)-p-cymene)Ru((CN)-N-boolean AND)-(X)](0/+) (X = Cl, py or 4-NMe2-py) containing a cyclometalated 2-ppy or 1-ppz with a non-coordinated CHO group as a handle for further functionalization have been synthesized to achieve selective cytotoxicity to cancer cells, the more potent compounds acting as proteosynthesis inhibitors, this is a new mode of action for half-sandwich metal complexes.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/GA18-09502S" target="_blank" >GA18-09502S: Targeting resistance to chemotherapy of tumor cells to reinstate their susceptibility to novel, existing and unsuccessful anticancer metallodrugs</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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