Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir-III Complex Conjugated to a Far-Red Emitting Coumarin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F19%3A00510188" target="_blank" >RIV/68081707:_____/19:00510188 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201901268" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201901268</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.201901268" target="_blank" >10.1002/anie.201901268</a>
Alternative languages
Result language
angličtina
Original language name
Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir-III Complex Conjugated to a Far-Red Emitting Coumarin
Original language description
Although cyclometalated Ir-III complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation, such as operability in the phototherapeutic window and reactive oxygen species (ROS) production efficiency and selectivity. In this work, a cyclometalated Ir-III complex conjugated to a far-red-emitting coumarin, Ir-III-COUPY, is reported with highly favourable properties for cancer phototherapy. Ir-III-COUPY was efficiently taken up by HeLa cells and showed no dark cytotoxicity and impressive photocytotoxicity indexes after irradiation with green and blue light, even under hypoxia. Importantly, a clear correlation between cell death and intracellular generation of superoxide anion radicals after visible light irradiation was demonstrated. This strategy opens the door to novel fluorescent photodynamic therapy agents with promising applications in theragnosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/GA18-09502S" target="_blank" >GA18-09502S: Targeting resistance to chemotherapy of tumor cells to reinstate their susceptibility to novel, existing and unsuccessful anticancer metallodrugs</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Angewandte Chemie - International Edition
ISSN
1433-7851
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
19
Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
6311-6315
UT code for WoS article
000471976400029
EID of the result in the Scopus database
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