DNA modification by cisplatin-like Pt(II) complexes containing 1,1 '-binaphtyl-2,2 '-diamine ligand does not correlate with their antiproliferative activity in cancer cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F19%3A00518335" target="_blank" >RIV/68081707:_____/19:00518335 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/19:73597237
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0020169319305912?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0020169319305912?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ica.2019.06.003" target="_blank" >10.1016/j.ica.2019.06.003</a>
Alternative languages
Result language
angličtina
Original language name
DNA modification by cisplatin-like Pt(II) complexes containing 1,1 '-binaphtyl-2,2 '-diamine ligand does not correlate with their antiproliferative activity in cancer cells
Original language description
DNA-reactive platinum complexes, such as cisplatin and its antitumor derivatives, are presupposed to kill actively proliferating cancer cells. Thus, the intense research of the mechanism of action (MoA) of this class of platinum drugs led to the conclusion that a major factor responsible for antitumor effects of conventional platinum drugs and their derivatives is DNA damage induced by their coordinative binding. Here, we present the results of the investigations aimed at clarification of the DNA binding modes of two direct derivatives of cisplatin, such as enantiomeric Pt(II) complexes, R- and S-1,1'-binaphthyl-2,2'-diaminodichlorido-Pt(II) complexes (R- and S[Pt(DABN)Cl-2]), and compared these modes to that of cisplatin. We show that the chirality of [Pt(DABN)Cl-2] complexes can markedly affect their DNA binding mode. On the other hand, the variations in DNA binding do not translate directly into cellular processing and toxicity in cancer cells. Thus, the results are consistent with the view and support the hypothesis that, in contrast to conventional platinum drugs and their derivatives, the DNA damage resulting from the binding of the [Pt(DABN)Cl-2] complexes is not a major factor accountable for their biological actions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/GA18-09502S" target="_blank" >GA18-09502S: Targeting resistance to chemotherapy of tumor cells to reinstate their susceptibility to novel, existing and unsuccessful anticancer metallodrugs</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inorganica chimica acta
ISSN
0020-1693
e-ISSN
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Volume of the periodical
495
Issue of the periodical within the volume
SEP 1 2019
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
118952
UT code for WoS article
000481728800021
EID of the result in the Scopus database
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