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HMGB2 is a negative regulator of telomerase activity in human embryonic stem and progenitor cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F19%3A00522120" target="_blank" >RIV/68081707:_____/19:00522120 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/19:00108537 RIV/00159816:_____/19:00072485

  • Result on the web

    <a href="https://www.fasebj.org/doi/pdf/10.1096/fj.201901465RRR" target="_blank" >https://www.fasebj.org/doi/pdf/10.1096/fj.201901465RRR</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1096/fj.201901465RRR" target="_blank" >10.1096/fj.201901465RRR</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    HMGB2 is a negative regulator of telomerase activity in human embryonic stem and progenitor cells

  • Original language description

    High-mobility group box (HMGB)1 and HMGB2 proteins are the subject of intensive research because of their involvement in DNA replication, repair, transcription, differentiation, proliferation, cell signaling, inflammation, and tumor migration. Using inducible, stably transfected human embryonic stem cells (hESCs) capable of the short hairpin RNA-mediated knockdown (KD) of HMGB1 and HMGB2, we provide evidence that deregulation of HMGB1 or HMGB2 expression in hESCs and their differentiated derivatives (neuroectodermal cells) results in distinct modulation of telomere homeostasis. Whereas HMGB1 enhances telomerase activity, HMGB2 acts as a negative regulator of telomerase activity in the cell. Stimulation of telomerase activity in the HMGB2-deficient cells may be related to activation of the PI3K/protein kinase B/ glycogen synthase kinase-313/ I3-catenin signaling pathways by HMGB1, augmented TERT/telomerase RNA subunit transcription, and possibly also because of changes in telomeric repeat-containing RNA (TERRA) and TERRA-polyA(+) transcription. The impact of HMGB1/2 KD on telomerase transcriptional regulation observed in neuroectodermal cells is partially masked in hESCs by their pluripotent state. Our findings on differential roles of HMGB1 and HMGB2 proteins in regulation of telomerase activity may suggest another possible outcome of HMGB1 targeting in cells, which is currently a promising approach aiming at increasing the anticancer activity of cytotoxic agents.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    FASEB Journal

  • ISSN

    0892-6638

  • e-ISSN

    1530-6860

  • Volume of the periodical

    33

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    18

  • Pages from-to

    14307-14324

  • UT code for WoS article

    000507466100097

  • EID of the result in the Scopus database

    2-s2.0-85076061677