UV-induced hydrogen transfer in DNA base pairs promoted by dark n pi* states
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F20%3A00524256" target="_blank" >RIV/68081707:_____/20:00524256 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/20:73604400
Result on the web
<a href="https://pubs.rsc.org/en/content/articlepdf/2020/cc/c9cc06180k" target="_blank" >https://pubs.rsc.org/en/content/articlepdf/2020/cc/c9cc06180k</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c9cc06180k" target="_blank" >10.1039/c9cc06180k</a>
Alternative languages
Result language
angličtina
Original language name
UV-induced hydrogen transfer in DNA base pairs promoted by dark n pi* states
Original language description
Dark n pi* states were shown to have substantial contribution to the destructive photochemistry of pyrimidine nucleobases. Based on quantum-chemical calculations, we demonstrate that the characteristic hydrogen bonding pattern of the GC base pair could facilitate the formation of a wobble excited-state charge-transfer n pi(CT)* complex. This entails a barrierless electron-driven proton transfer (EDPT) process which enables damageless photodeactivation of the base pair. These photostabilizing properties are retained even when guanine is exchanged to hypoxanthine. The inaccessibility of this process in the AT base pair sheds further light on the reasons why cytosine is less susceptible to the formation of photodimers in double-stranded DNA.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/EF15_003%2F0000477" target="_blank" >EF15_003/0000477: Structural gymnastics of nucleic acids: from molecular principles through biological functions to therapeutic targets.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemical Communications
ISSN
1359-7345
e-ISSN
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Volume of the periodical
56
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
201-204
UT code for WoS article
000503765300030
EID of the result in the Scopus database
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