ZEB1: A Critical Regulator of Cell Plasticity, DNA Damage Response, and Therapy Resistance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F20%3A00524939" target="_blank" >RIV/68081707:_____/20:00524939 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/20:00072903 RIV/00216224:14310/20:00115785 RIV/61989592:15110/20:73602833
Result on the web
<a href="https://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=AdvancedSearch&qid=8&SID=D4ZqAnHn6WSkCM83tcu&page=2&doc=20" target="_blank" >https://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=AdvancedSearch&qid=8&SID=D4ZqAnHn6WSkCM83tcu&page=2&doc=20</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fmolb.2020.00036" target="_blank" >10.3389/fmolb.2020.00036</a>
Alternative languages
Result language
angličtina
Original language name
ZEB1: A Critical Regulator of Cell Plasticity, DNA Damage Response, and Therapy Resistance
Original language description
The predominant way in which conventional chemotherapy kills rapidly proliferating cancer cells is the induction of DNA damage. However, chemoresistance remains the main obstacle to therapy effectivity. An increasing number of studies suggest that epithelial-to-mesenchymal transition (EMT) represents a critical process affecting the sensitivity of cancer cells to chemotherapy. Zinc finger E-box binding homeobox 1 (ZEB1) is a prime element of a network of transcription factors controlling EMT and has been identified as an important molecule in the regulation of DNA damage, cancer cell differentiation, and metastasis. Recent studies have considered upregulation of ZEB1 as a potential modulator of chemoresistance. It has been hypothesized that cancer cells undergoing EMT acquire unique properties that resemble those of cancer stem cells (CSCs). These stem-like cells manifest enhanced DNA damage response (DDR) and DNA repair capacity, self-renewal, or chemoresistance. In contrast, functional experiments have shown that ZEB1 induces chemoresistance regardless of whether other EMT-related changes occur. ZEB1 has also been identified as an important regulator of DDR by the formation of a ZEB1/p300/PCAF complex and direct interaction with ATM kinase, which has been linked to radioresistance. Moreover, ATM can directly phosphorylate ZEB1 and enhance its stability. Downregulation of ZEB1 has also been shown to reduce the abundance of CHK1, an effector kinase of DDR activated by ATR, and to induce its ubiquitin-dependent degradation. In this perspective, we focus on the role of ZEB1 in the regulation of DDR and describe the mechanisms of ZEB1-dependent chemoresistance.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in molecular biosciences
ISSN
2296-889X
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
MAR 19 2020
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
36
UT code for WoS article
000525671300001
EID of the result in the Scopus database
2-s2.0-85082693724