Low-dimensional compounds containing bioactive ligands. Part XV: Antiproliferative activity of tris(5-nitro-8-quinolinolato)gallium(III) complex with noticeable selectivity against the cancerous cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F20%3A00537740" target="_blank" >RIV/68081707:_____/20:00537740 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/20:10415751 RIV/61989592:15310/20:73603656
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0277538720303296?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0277538720303296?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.poly.2020.114672" target="_blank" >10.1016/j.poly.2020.114672</a>
Alternative languages
Result language
angličtina
Original language name
Low-dimensional compounds containing bioactive ligands. Part XV: Antiproliferative activity of tris(5-nitro-8-quinolinolato)gallium(III) complex with noticeable selectivity against the cancerous cells
Original language description
Three gallium(III) complexes, [Ga(NQ)(3)] (1), Na-3[Ga(SQ)(3)]center dot 7H(2)O center dot 3NaCl (2) and [Ga(CINQ)(3)]center dot MeOH (3) were synthesised as possible anticancer agents (H-NQ= 5-nitro-8-quinolinol, H-SQH = 5-sulfo-8-quinolinol, H-CINQ= 5-chloro-7-nitro-8-quinolinol) and characterised by elemental analysis, IR and NMR spectroscopy. Single crystal structure analysis of 1 revealed two crystallographically independent [Ga(NQ)(3)] molecules in the asymmetric part of the unit cell. Stability of the complexes 1 and 2 in solution was determined by H-1 NMR spectroscopy. Complex 3 was not further studied due to the low solubility. Antiproliferative activity of complexes 1 and 2 was studied using in vitro MIT assay against the A2780, HCT116 and MDA-MB-231 cancer cell lines and the selectivity of the complexes was verified on non-cancerous MRCS pd30 cell line. Complex 1 showed high antiproliferative potency (IC50 = 3.6 +/- 0.8 mu M for HCT116) and noticeable selectivity of 1 against the cancer cell lines (IC50 = 32 +/- 4 mu M for normal MRCS pd30 cell line) was also found. The complex 2 displayed the highest antioxidant activity of all tested complexes and free ligands. (C) 2020 Elsevier Ltd. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/GA18-09502S" target="_blank" >GA18-09502S: Targeting resistance to chemotherapy of tumor cells to reinstate their susceptibility to novel, existing and unsuccessful anticancer metallodrugs</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polyhedron
ISSN
0277-5387
e-ISSN
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Volume of the periodical
187
Issue of the periodical within the volume
2020
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
114672
UT code for WoS article
000556764100028
EID of the result in the Scopus database
2-s2.0-85086725258