TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F20%3A00538179" target="_blank" >RIV/68081707:_____/20:00538179 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/20:00072998 RIV/00216224:14310/20:00117612
Result on the web
<a href="https://doi.org/10.1038/s41598-020-67827-4" target="_blank" >https://doi.org/10.1038/s41598-020-67827-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-020-67827-4" target="_blank" >10.1038/s41598-020-67827-4</a>
Alternative languages
Result language
angličtina
Original language name
TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells
Original language description
The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-beta family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10620 - Other biological topics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
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UT code for WoS article
000548564900110
EID of the result in the Scopus database
2-s2.0-85087798740