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TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F20%3A00538179" target="_blank" >RIV/68081707:_____/20:00538179 - isvavai.cz</a>

  • Alternative codes found

    RIV/00159816:_____/20:00072998 RIV/00216224:14310/20:00117612

  • Result on the web

    <a href="https://doi.org/10.1038/s41598-020-67827-4" target="_blank" >https://doi.org/10.1038/s41598-020-67827-4</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/s41598-020-67827-4" target="_blank" >10.1038/s41598-020-67827-4</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells

  • Original language description

    The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-beta family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10620 - Other biological topics

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Scientific Reports

  • ISSN

    2045-2322

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    12

  • Pages from-to

  • UT code for WoS article

    000548564900110

  • EID of the result in the Scopus database

    2-s2.0-85087798740