SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island loci
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F21%3A00555382" target="_blank" >RIV/68081707:_____/21:00555382 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17310/21:A22029UR RIV/00216224:14310/21:00121025
Result on the web
<a href="https://academic.oup.com/bib/article/22/2/1338/6042389" target="_blank" >https://academic.oup.com/bib/article/22/2/1338/6042389</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/bib/bbaa385" target="_blank" >10.1093/bib/bbaa385</a>
Alternative languages
Result language
angličtina
Original language name
SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island loci
Original language description
SARS-CoV-2 is an intensively investigated virus from the order Nidovirales (Coronaviridae family) that causes COVID-19 disease in humans. Through enormous scientific effort, thousands of viral strains have been sequenced to date, thereby creating a strong background for deep bioinformatics studies of the SARS-CoV-2 genome. In this study, we inspected high-frequency mutations of SARS-CoV-2 and carried out systematic analyses of their overlay with inverted repeat (IR) loci and CpG islands. The main conclusion of our study is that SARS-CoV-2 hot-spot mutations are significantly enriched within both IRs and CpG island loci. This points to their role in genomic instability and may predict further mutational drive of the SARS-CoV-2 genome. Moreover, CpG islands are strongly enriched upstream from viral ORFs and thus could play important roles in transcription and the viral life cycle. We hypothesize that hypermethylation of these loci will decrease the transcription of viral ORFs and could therefore limit the progression of the disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Briefings in Bioinformatics
ISSN
1467-5463
e-ISSN
1477-4054
Volume of the periodical
22
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
1338-1345
UT code for WoS article
000642298000058
EID of the result in the Scopus database
2-s2.0-85103474633