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SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island loci

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F21%3A00555382" target="_blank" >RIV/68081707:_____/21:00555382 - isvavai.cz</a>

  • Alternative codes found

    RIV/61988987:17310/21:A22029UR RIV/00216224:14310/21:00121025

  • Result on the web

    <a href="https://academic.oup.com/bib/article/22/2/1338/6042389" target="_blank" >https://academic.oup.com/bib/article/22/2/1338/6042389</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1093/bib/bbaa385" target="_blank" >10.1093/bib/bbaa385</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island loci

  • Original language description

    SARS-CoV-2 is an intensively investigated virus from the order Nidovirales (Coronaviridae family) that causes COVID-19 disease in humans. Through enormous scientific effort, thousands of viral strains have been sequenced to date, thereby creating a strong background for deep bioinformatics studies of the SARS-CoV-2 genome. In this study, we inspected high-frequency mutations of SARS-CoV-2 and carried out systematic analyses of their overlay with inverted repeat (IR) loci and CpG islands. The main conclusion of our study is that SARS-CoV-2 hot-spot mutations are significantly enriched within both IRs and CpG island loci. This points to their role in genomic instability and may predict further mutational drive of the SARS-CoV-2 genome. Moreover, CpG islands are strongly enriched upstream from viral ORFs and thus could play important roles in transcription and the viral life cycle. We hypothesize that hypermethylation of these loci will decrease the transcription of viral ORFs and could therefore limit the progression of the disease.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Briefings in Bioinformatics

  • ISSN

    1467-5463

  • e-ISSN

    1477-4054

  • Volume of the periodical

    22

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    1338-1345

  • UT code for WoS article

    000642298000058

  • EID of the result in the Scopus database

    2-s2.0-85103474633