WNT5B in Physiology and Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F21%3A00555638" target="_blank" >RIV/68081707:_____/21:00555638 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/21:00121666
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fcell.2021.667581/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcell.2021.667581/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcell.2021.667581" target="_blank" >10.3389/fcell.2021.667581</a>
Alternative languages
Result language
angličtina
Original language name
WNT5B in Physiology and Disease
Original language description
WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical beta-catenin-independent signaling pathway and often functions as an antagonist of canonical WNT signaling. Although WNT5B has a high amino acid identity with WNT5A and is often assumed to have similar activities, WNT5B often exhibits unique expression patterns and functions. Here, we describe the distinct effects and mechanisms of WNT5B on development, bone, adipose tissue, cardiac tissue, the nervous system, the mammary gland, the lung and hematopoietic cells, compared to WNT5A. We also highlight aberrances in non-canonical WNT5B signaling contributing to diseases such as osteoarthritis, osteoporosis, obesity, type 2 diabetes mellitus, neuropathology, and chronic diseases associated with aging, as well as various cancers.
Czech name
—
Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/EF16_025%2F0007381" target="_blank" >EF16_025/0007381: Preclinical Progression of New Organic Compounds with Targeted Biological Activity</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cell and Developmental Biology
ISSN
2296-634X
e-ISSN
2296-634X
Volume of the periodical
09
Issue of the periodical within the volume
MAY 4 2021
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
667581
UT code for WoS article
000651394300001
EID of the result in the Scopus database
2-s2.0-85106051215