Regulation of Neuroendocrine-like Differentiation in Prostate Cancer by Non-Coding RNAs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F21%3A00604190" target="_blank" >RIV/68081707:_____/21:00604190 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2311-553X/7/4/75" target="_blank" >https://www.mdpi.com/2311-553X/7/4/75</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ncrna7040075" target="_blank" >10.3390/ncrna7040075</a>
Alternative languages
Result language
angličtina
Original language name
Regulation of Neuroendocrine-like Differentiation in Prostate Cancer by Non-Coding RNAs
Original language description
Neuroendocrine prostate cancer (NEPC) represents a variant of prostate cancer that occurs in response to treatment resistance or, to a much lesser extent, de novo. Unravelling the molecular mechanisms behind transdifferentiation of cancer cells to neuroendocrine-like cancer cells is essential for development of new treatment opportunities. This review focuses on summarizing the role of small molecules, predominantly microRNAs, in this phenomenon. A published literature search was performed to identify microRNAs, which are reported and experimentally validated to modulate neuroendocrine markers and/or regulators and to affect the complex neuroendocrine phenotype. Next, available patients' expression datasets were surveyed to identify deregulated microRNAs, and their effect on NEPC and prostate cancer progression is summarized. Finally, possibilities of miRNA detection and quantification in body fluids of prostate cancer patients and their possible use as liquid biopsy in prostate cancer monitoring are discussed. All the addressed clinical and experimental contexts point to an association of NEPC with upregulation of miR-375 and downregulation of miR-34a and miR-19b-3p. Together, this review provides an overview of different roles of non-coding RNAs in the emergence of neuroendocrine prostate cancer.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/NV17-28518A" target="_blank" >NV17-28518A: Toll-like receptors in prostate carcinogenesis and therapy resistance</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Non-coding RNA
ISSN
2311-553X
e-ISSN
2311-553X
Volume of the periodical
7
Issue of the periodical within the volume
4
Country of publishing house
CH - SWITZERLAND
Number of pages
40
Pages from-to
75
UT code for WoS article
000913831400001
EID of the result in the Scopus database
2-s2.0-85121649416