Photoinduced water-chromophore electron transfer causes formation of guanosine photodamage
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00556523" target="_blank" >RIV/68081707:_____/22:00556523 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/22:00127885
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2022/CP/D2CP00801G" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2022/CP/D2CP00801G</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d2cp00801g" target="_blank" >10.1039/d2cp00801g</a>
Alternative languages
Result language
angličtina
Original language name
Photoinduced water-chromophore electron transfer causes formation of guanosine photodamage
Original language description
UV-induced photolysis of aqueous guanine nucleosides produces 8-oxo-guanine and Fapy-guanine, which can induce various types of cellular malfunction. The mechanistic rationale underlying photodestructive processes of guanine nucleosides is still largely obscure. Here, we employ accurate quantum chemical calculations and demonstrate that an excited-state non-bonding interaction of guanosine and a water molecule facilitates the electron-driven proton transfer process from water to the chromophore fragment. This subsequently allows for the formation of a crucial intermediate, namely guanosine photohydrate. Further (photo)chemical reactions of this intermediate lead to the known products of guanine photodamage.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physical Chemistry Chemical Physics
ISSN
1463-9076
e-ISSN
1463-9084
Volume of the periodical
24
Issue of the periodical within the volume
14
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
8217-8224
UT code for WoS article
000772126600001
EID of the result in the Scopus database
2-s2.0-85128116652