TACSTD2 upregulation is an early reaction to lung infection
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00558970" target="_blank" >RIV/68081707:_____/22:00558970 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/22:00077733 RIV/00216224:14310/22:00126036 RIV/65269705:_____/22:00077733
Result on the web
<a href="https://www.nature.com/articles/s41598-022-13637-9" target="_blank" >https://www.nature.com/articles/s41598-022-13637-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-022-13637-9" target="_blank" >10.1038/s41598-022-13637-9</a>
Alternative languages
Result language
angličtina
Original language name
TACSTD2 upregulation is an early reaction to lung infection
Original language description
TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved for cancer therapy, the physiological role of Trop2 is still not fully understood. In this article, we show that TACSTD2/Trop2 expression is evolutionarily conserved in lungs of various vertebrates. By analysis of publicly available transcriptomic data we demonstrate that TACSTD2 level consistently increases in lungs infected with miscellaneous, but mainly viral pathogens. Single cell and subpopulation based transcriptomic data revealed that the major source of TACSTD2 transcript are lung epithelial cells and their progenitors and that TACSTD2 is induced directly in lung epithelial cells following infection. Increase in TACSTD2 expression may represent a mechanism to maintain/restore epithelial barrier function and contribute to regeneration process in infected/damaged lungs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
12
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
15
Pages from-to
9583
UT code for WoS article
000809441100064
EID of the result in the Scopus database
2-s2.0-85131713627