Is antitumor Pt(IV) complex containing two axial lonidamine ligands a true dual- or multi-action prodrug?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00559611" target="_blank" >RIV/68081707:_____/22:00559611 - isvavai.cz</a>
Result on the web
<a href="https://academic.oup.com/metallomics/article/14/7/mfac048/6618656?login=true" target="_blank" >https://academic.oup.com/metallomics/article/14/7/mfac048/6618656?login=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/mtomcs/mfac048" target="_blank" >10.1093/mtomcs/mfac048</a>
Alternative languages
Result language
angličtina
Original language name
Is antitumor Pt(IV) complex containing two axial lonidamine ligands a true dual- or multi-action prodrug?
Original language description
This work studied the mechanism of action of a Pt(IV) complex 2 bearing two axial lonidamine ligands, which are selective inhibitors of aerobic glycolysis. The presence of two lonidamine ligands in 2 compared to the parent Pt(II) complex increased its antiproliferative activity, cellular accumulation, and changed its cell cycle profile and mechanism of cell death. In 3D cell culture, 2 showed exceptional antiproliferative activity with IC50 values as low as 1.6 mu M in MCF7 cells. The study on the influence of the lonidamine ligands in the Pt complex on glycolysis showed only low potency of ligands to affect metabolic processes in cancer cells, making the investigated complex, not a dual- or multi-action prodrug. However, the Pt(IV) prodrug effectively delivers the cytotoxic Pt(II) complex into cancer cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GC20-14082J" target="_blank" >GC20-14082J: Development of new, targeting polynuclear platinum and ruthenium complexes for anticancer chemotherapy. Mechanism of action</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Metallomics
ISSN
1756-5901
e-ISSN
1756-591X
Volume of the periodical
14
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
mfac048
UT code for WoS article
000827780700001
EID of the result in the Scopus database
2-s2.0-85134721431