Clustered DNA Damage Formation in Human Cells after Exposure to Low- and Intermediate-Energy Accelerated Heavy Ions

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00559818" target="_blank" >RIV/68081707:_____/22:00559818 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1134/S1547477122040227" target="_blank" >https://link.springer.com/article/10.1134/S1547477122040227</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1134/S1547477122040227" target="_blank" >10.1134/S1547477122040227</a>

Result language

angličtina

Original language name

Clustered DNA Damage Formation in Human Cells after Exposure to Low- and Intermediate-Energy Accelerated Heavy Ions

Original language description

Based on the differentiated analysis of individual radiation-induced foci in three-dimensional images reconstructing the entire volume of the cell nucleus, a detailed analysis of the structure of complex DNA damage clusters in accelerated ion tracks is carried out, and the differences in damage cluster morphology are investigated. It has been found that after exposure to accelerated heavy ions of low and intermediate energies, unlike gamma-rays, complex clusters are formed, including up to six and more individual foci. The obtained results showed that the structure of clustered DNA damage depend on particle LET. The kinetics of the elimination of radiation-induced foci in cells after heavy ion exposure is shown to be slower than after gamma-irradiation. It is concluded that the delay in kinetics is associated with the nature of the microdistribution of heavy charged particles' energy in genetic structures and the formation of complex DNA double-strand breaks (DSBs), which are difficult to repair. A study of the kinetics of radiation-induced foci formation and elimination after exposure to accelerated boron, nitrogen, and neon ions with different physical characteristics has shown that with a decrease in the particles' energy and an increase in their LET, the effectiveness of DNA DSB repair decreases. It is shown that the structure of radiation-induced foci caused by accelerated ions with different physical characteristics is also different. Neon ions with a high density of delta-electrons in the track induce larger and more complex foci clusters.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physics of Particles and Nuclei Letters

ISSN

1547-4771

e-ISSN

—

Volume of the periodical

19

Issue of the periodical within the volume

4

Country of publishing house

RU - RUSSIAN FEDERATION

Number of pages

11

Pages from-to

440-450

UT code for WoS article

000830723400021

EID of the result in the Scopus database

2-s2.0-85134730442