Transcriptional regulators of human oncoviruses: structural and functional implications for anticancer therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00569833" target="_blank" >RIV/68081707:_____/22:00569833 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/22:00125582

Result on the web

<a href="https://academic.oup.com/narcancer/article/4/1/zcac005/6541525?login=true" target="_blank" >https://academic.oup.com/narcancer/article/4/1/zcac005/6541525?login=true</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/narcan/zcac005" target="_blank" >10.1093/narcan/zcac005</a>

Result language

angličtina

Original language name

Transcriptional regulators of human oncoviruses: structural and functional implications for anticancer therapy

Original language description

Transcription is often the first biosynthetic event of viral infection. Viruses produce preferentially viral transcriptional regulators (vTRs) essential for expressing viral genes and regulating essential host cell proteins to enable viral genome replication. As vTRs are unique viral proteins that promote the transcription of viral nucleic acid, vTRs interact with host proteins to suppress detection and immune reactions to viral infection. Thus, vTRs are promising therapeutic targets that are sequentially and structurally distinct from host cell proteins. Here, we review vTRs of three human oncoviruses: HBx of hepatitis B virus, HBZ of human T-lymphotropic virus type 1, and Rta of Epstein-Barr virus. We present three cunningly exciting and dangerous transcription strategies that make viral infections so efficient. We use available structural and functional knowledge to critically examine the potential of vTRs as new antiviral-anticancer therapy targets. For each oncovirus, we describe (i) the strategy of viral genome transcription, (ii) vTRs' structure and binding partners essential for transcription regulation, and (iii) advantages and challenges of vTR targeting in antiviral therapies. We discuss the implications of vTR regulation for oncogenesis and perspectives on developing novel antiviral and anticancer strategies.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NAR CANCER

ISSN

2632-8674

e-ISSN

—

Volume of the periodical

4

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

—

UT code for WoS article

000925421400008

EID of the result in the Scopus database

2-s2.0-85141079091