Single-cell protein profiling defines cell populations associated with triple-negative breast cancer aggressiveness
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F23%3A00574522" target="_blank" >RIV/68081707:_____/23:00574522 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/23:00130413 RIV/00216208:11130/23:10452827 RIV/00216208:11310/23:10452827 RIV/61989592:15110/23:73624727 and 4 more
Result on the web
<a href="https://febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13365" target="_blank" >https://febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13365</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/1878-0261.13365" target="_blank" >10.1002/1878-0261.13365</a>
Alternative languages
Result language
angličtina
Original language name
Single-cell protein profiling defines cell populations associated with triple-negative breast cancer aggressiveness
Original language description
Triple-negative breast cancer (TNBC) is an aggressive and complex subtype of breast cancer that lacks targeted therapy. TNBC manifests characteristic, extensive intratumoral heterogeneity that promotes disease progression and influences drug response. Single-cell techniques in combination with next-generation computation provide an unprecedented opportunity to identify molecular events with therapeutic potential. Here, we describe the generation of a comprehensive mass cytometry panel for multiparametric detection of 23 phenotypic markers and 13 signaling molecules. This single-cell proteomic approach allowed us to explore the landscape of TNBC heterogeneity, with particular emphasis on the tumor microenvironment. We prospectively profiled freshly resected tumors from 26 TNBC patients. These tumors contained phenotypically distinct subpopulations of cancer and stromal cells that were associated with the patient's clinical status at the time of surgery. We further classified the epithelial-mesenchymal plasticity of tumor cells, and molecularly defined phenotypically diverse populations of tumor-associated stroma. Furthermore, in a retrospective tissue-microarray TNBC cohort, we showed that the level of CD97 at the time of surgery has prognostic potential.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Oncology
ISSN
1574-7891
e-ISSN
1878-0261
Volume of the periodical
17
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
1024-1040
UT code for WoS article
000926769000001
EID of the result in the Scopus database
2-s2.0-85147231039